https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47674 Tue 24 Jan 2023 16:02:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53941 Mon 22 Jan 2024 16:56:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52693 256 mg/L) within 2 to 7 weeks and at 5 to 12 weeks, respectively. B. pertussis remained phenotypically susceptible to the antibiotic following 15 weeks of exposure, with the MIC between 0.032 to 0.38 mg/L. Genomic analysis revealed that B. holmesii developed resistance due to mutations in the 23S rRNA gene. The resistance mechanism in B. parapertussis was hypothesized as being due to upregulation of an efflux pump mechanism. Conclusions: These findings indicate that both B. holmesii and B. parapertussis can be more prone to induced resistance following exposure to treatment with erythromycin than B. pertussis. The surveillance of macrolide resistance in Bordetella isolates recovered from patients with pertussis, especially persistent disease, is warranted.]]> Fri 20 Oct 2023 15:55:42 AEDT ]]>